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Dibenzo[1,2,5]thiadiazepines are non-competitive GABAA receptor antagonists
(MDPI, 2013)
"A new process for obtaining dibenzo[c,f][1,2,5]thiadiazepines (DBTDs) and their effects on GABAA receptors of guinea pig myenteric neurons are described. Synthesis of DBTD derivatives began with two commercial aromatic ...
Genomic organization of purinergic P2X receptors
(2015-08)
"Purinergic P2X receptors are a family of ligand-gated cationic channels activated by extracellular ATP. P2X subunit protein sequences are highly conserved between vertebrate species. However, they can generate a great ...
Recreating intestinal peristalsis in the petri dish
(Humana Press Inc, 2017)
"Here we describe a culture technique of cells dissociated from the external muscularis of the guinea pig small intestine, which allows us to maintain all the elements involved in the intestinal peristaltic reflex. After ...
Cholinergic signaling plasticity maintains viscerosensory responses during Aspiculuris tetraptera infection in mice small intestine
(Elsevier, 2017)
"Intestinal parasites alter gastrointestinal (GI) functions like the cholinergic function. Aspiculuris tetraptera is a pinworm frequently observed in laboratory facilities, which infests the mice cecum and proximal colon. ...
Two P2X1 receptor transcripts able to form functional channels are present in most human monocytes
(Elsevier, 2016)
"To characterize the presence and general properties of P2X1 receptors in single human monocytes we used RT-PCR, flow cytometry, and the patch-clamp and the two-electrode voltage-clamp techniques. Most human monocytes ...
Physiological concentrations of zinc have dual effects on P2X myenteric receptors of guinea pig
(Springer, 2018)
"We, hereby, characterize the pharmacological effects of physiological concentrations of Zinc on native myenteric P2X receptors from guinea-pig small intestine and on P2X2 isoforms present in most myenteric neurons. This ...
Purinergic signaling pathway in human olfactory neuronal precursor cells
(Hindawi Publishing Corporation, 2019)
"Extracellular ATP and trophic factors released by exocytosis modulate in vivo proliferation, migration, and differentiation in multipotent stem cells (MpSC); however, the purinoceptors mediating this signaling remain ...
Ano1 is a better marker than c-Kit for transcript analysis of single interstitial cells of Cajal in culture
(Walter de Gruyter GmbH, 2014)
"The interstitial cells of Cajal (ICC) drive the slow wave-associated contractions in the small intestine. A commonly used marker for these cells is c-Kit, but another marker named Ano1 was recently described. This study ...
Pharmacological Properties of P2X Receptors in Human Macrophages
(Universidad Autónoma de Nayarit, 2019)