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Substrate-induced dimerization of engineered monomeric variants of triosephosphate isomerase from Trichomonas vaginalis
(2015-11)
"The dimeric nature of triosephosphate isomerases (TIMs) is maintained by an extensive surface area interface of more than 1600 angstrom 2. TIMs from Trichomonas vaginalis (TvTIM) are held in their dimeric state by two ...
Structural basis for redox regulation of cytoplasmic and chloroplastic triosephosphate isomerases from Arabidopsis thaliana
(Frontiers Media S.A., 2016-12)
"In plants triosephosphate isomerase (TPI) interconyerts glyceraldehyde 3-phosphate (G3P) and dihydroxyacetone phosphate (DHAP) during glycolysis, gluconeogenesis, and the Calvin-Benson cycle. The nuclear genome of land ...
Structural insights into the IgE mediated responses induced by the allergens Hev b 8 and Zea m 12 in their dimeric forms
(2016-09)
"Oligomerization of allergens plays an important role in IgE-mediated reactions, as effective crosslinking of IgE-Fc epsilon RI complexes on the cell membrane is dependent on the number of exposed B-cell epitopes in a ...
A competent catalytic active site is necessary for substrate induced dimer assembly in triosephosphate isomerase
(Elsevier, 2017)
"The protozoan parasite Trichomonas vaginalis contains two nearly identical triosephosphate isomerases (TvTIMs) that dissociate into stable monomers and dimerize upon substrate binding. Herein, we compare the role of the ...
Self-association of enolase from Trichomonas vaginalis. monomers, dimers, and octamers coexist in solution
(American Chemical Society, 2018)
"We used small-angle X-ray scattering to study the self-association of enolase from Trichomonas vaginalis as a function of the protein concentration and cosolute type. We observed coexisting monomers, dimers, and octamers ...
Bioinformatic Analysis and Biophysical Characterization Reveal Structural Disorder in G0S2 Protein
(American Chemical Society, 2020)
"G0S2 is a small protein of 103 residues in length that is involved in multiple cellular processes. To date, several reports have shown that G0S2 functions by making direct protein杙rotein interactions with key proteins. ...
Improved Stability of Human CGI-58 Induced by Phosphomimetic S237E Mutation
(American Chemical Society, 2022)
"In lipolysis, the activating function of CGI-58 is regulated by its interaction with perilipin 1 (PLIN1) localized on the lipid droplet (LD), and its release is controlled by phosphorylation. Once lipolysis is stimulated ...