División de Biología Molecular
Recent Submissions
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Cytotoxic effects and changes in genetic expression on human vascular endothelial cells by DINP and DEHT
(2025-06-30)"Los ftalatos son plastificantes ampliamente utilizados para mejorar la flexibilidad de polímeros rígidos como el policloruro de vinilo (PVC); sin embargo, han generado preocupación debido a su potencial citotóxico y su ... -
SERPINA3 is expressed in human adipocytes and modulated by TNF-α and vitamin B6
(2025-05-28)"BACKGROUND. The SERPINA3G gene participates in antiadipogenesis and insulin resistance induced by TNF-α in 3T3-F442A murine cells. Since this gene has a human orthologue, SERPINA3, we explored if its plays similar roles ... -
Small RNA 2 from the beneficial fungus Trichoderma atroviride targets plant gene At-EDA9 of Arabidopsis thaliana to establish a mutualistic relationship
(2024-11-28)"En la rizosfera, las plantas interactúan con diversos microbiomas que pueden incluir microorganismos como bacterias, oomicetos y hongos. Como organismos sésiles, las plantas han desarrollado variados mecanismos de ... -
La glicosiltransferasa UGT89A2 de Nicotiana tabacum modifica derivados di- y trihidroxilados del ácido benzoico
(2024-12-04)"Las glicosiltransferasas (GTs) desempeñan un papel crucial en la transferencia de grupos glicosilo a varios compuestos aceptores, generando glicoconjugados que participan en múltiples procesos biológicos y farmacológicos. ... -
Análisis inmunológico de una proteína contra influenza A H1N1 producida en microalgas y diseño de una proteína antigénica contra influenza A H1N1 y A H3N2
(2024-11)"El virus de la influenza tipo A causa infecciones y complicaciones respiratorias y ha protagonizado pandemias con un alto número de muertes. La vacunación es la herramienta fundamental para combatir la enfermedad y sus ... -
Characterization of ABC-type transporters in Candida glabrata.
(2024-07)"Candida glabrata is an opportunistic fungal pathogen that accounts for approximately 25% of cases of invasive candidiasis. Its morbidity and mortality rates are around 40-60% due to its innate and acquired resistance to ... -
Chromatin remodeling protein Abf1 regulates expression of adhesin encoding genes in Candida glabrata
(2024-07)"The DNA spatial arrangement inside the nucleus critically depends on external stimuli and plays a fundamental role in gene expression. In the fungal opportunistic pathogen Candida glabrata (Nakaseomyces glabrata), gene ... -
CHARACTERIZATION OF THE RESPONSE OF Candida glabrata (Nakaseomyces glabratus) CLINICAL ISOLATES TO NEUTROPHILS
(2024-07-14)"Las infecciones por patógenos fúngicos están aumentando debido al incremento de la población inmunocomprometida. Algunos de los patógenos fúngicos más comunes del género Candida adquieren resistencia a los antifúngicos ... -
Microevolution of Candida glabrata in the presence of fluconazole
(2024-06)"Debido a la resistencia a los antifúngicos, las infecciones oportunistas causadas por C. glabrata representan riesgos para individuos inmunocomprometidos. Este estudio investiga el papel de la función mitocondrial y la ... -
An Observation of a Very High Swelling of Bromovirus Members at Specific Ionic Strengths and pH
(MDPI, 2023)Cowpea chlorotic mottle virus (CCMV) and brome mosaic virus (BMV) are naked plant viruses with similar characteristics; both form a T = 3 icosahedral protein capsid and are members of the bromoviridae family. It is well ... -
Multiplex assay for the simultaneous detection of antibodies against small ruminant lentivirus, Mycobacterium avium subsp. paratuberculosis, and Brucella melitensis in goats
(Veterinary World, 2023)Background and Aim: Brucellosis, paratuberculosis (PTb), and infections caused by small ruminant lentivirus (SRLV), formerly known as caprine arthritis encephalitis virus (CAEV), adversely affect goat production systems. ... -
Cell-type dependent regulation of pluripotency and chromatin remodeling genes by hydralazine
(Springer Nature, 2023)Background The generation of induced pluripotent stem cells has opened the field of study for stem cell research, disease modeling and drug development. However, the epigenetic signatures present in somatic cells make cell ... -
Neo-functionalization in Saccharomyces cerevisiae: a novel Nrg1-Rtg3 chimeric transcriptional modulator is essential to maintain mitochondrial DNA integrity
(The Royal Society, 2023)In Saccharomyces cerevisiae, the transcriptional repressor Nrg1 (Negative Regulator of Glucose-repressed genes) and the ?-Zip transcription factor Rtg3 (ReTroGrade regulation) mediate glucose repression and signalling from ... -
Phenolic Compounds in Agro-Industrial Waste of Mango Fruit: Impact on Health and Prebiotic Effect – a Review
(Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences in Olsztyn, 2023)The fruit processing industry generates huge amounts of waste annually, causing severe environmental problems. Mango processing produces around 20 million tons of wastes from the non-consumed fraction, mainly peels and ... -
Graphene–Cu Nanocomposites Induce Tolerance against Fusarium oxysporum, Increase Antioxidant Activity, and Decrease Stress in Tomato Plants
(MDPI, 2023)The tomato crop is susceptible to various types of stress, both biotic and abiotic, which affect the morphology, physiology, biochemistry, and genetic regulation of plants. Among the biotic factors, is the phytopathogen ... -
Expression of EPL1 from Trichoderma atroviride in Arabidopsis Confers Resistance to Bacterial and Fungal Pathogens
(MDPI, 2023)During plant interaction with beneficial microorganisms, fungi secrete a battery of elicitors that trigger plant defenses against pathogenic microorganisms. Among the elicitor molecules secreted by Trichoderma are ... -
Neuropharmacological Effects of the Dichloromethane Extract from the Stems of Argemone ochroleuca Sweet (Papaveraceae) and Its Active Compound Dihydrosanguinarine
(MDPI, 2023)Argemone ochroleuca Sweet (Papaveraceae) is used in folk medicine as a sedative and hypnotic agent. This study aimed to evaluate the anxiolytic-like, sedative, antidepressant-like, and anticonvulsant activities of a ... -
In Vivo Neuropharmacological Effects of Neophytadiene
(MDPI, 2023)Neophytadiene (NPT) is a diterpene found in the methanolic extracts of Crataeva nurvala and Blumea lacera, plants reported with anxiolytic-like activity, sedative properties, and antidepressant-like actions; however, the ... -
Advances in the Properties of Incomptine A: Cytotoxic Activity and Downregulation of Hexokinase II in Breast Cancer Cell Lines
(MDPI, 2023)Breast cancer treatments are limited by the cancer subtype and its selectivity towards tumor cells, hence the importance of finding compounds that increase the survival of healthy cells and target any subtype. Incomptine ... -
Selective Activation of D3 Dopamine Receptors Ameliorates DOI-Induced Head Twitching Accompanied by Changes in Corticostriatal Processing
(MDPI, 2023)D3 receptors, a key component of the dopamine system, have emerged as a potential target of therapies to improve motor symptoms across neurodegenerative and neuropsychiatric conditions. In the present work, we evaluated ...