Glucose regulation in type 1 diabetic patients by a multi-doses regimen

Abstract

"In this paper several multi-doses control regimens are suggested for type 1 diabetic patients. The suggested regimes are proposed based on different insulin formulations. The insulin doses are assumed to be infused by a subcutaneous injection in a three daily regimen prior to each meal. Mixing two types of insulin: rapid or short, and intermediate or long action, the basal and postprandial insulin productions of the pancreas are reproduced. The performance in the glucose regulation is evaluated during a 10-day trial by open-loop and closed-loop simulation with a compartmental model."