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Amaranth protein improves lipid profile and insulin resistance in a diet-induced obese mice model

dc.contributor.authorEscobedo-Moratilla, Abraham
dc.contributor.authorVelarde Salcedo, Aida Jimena
dc.contributor.authorMagaña Hernández, Cynthia Victoria
dc.contributor.authorBarrera Pacheco, Alberto
dc.contributor.authorEspitia Rangel, Eduardo
dc.contributor.authorBarba de la Rosa, Ana Paulina
dc.contributor.authorHerrera Estrella, Alfredo Heriberto
dc.contributor.editorScience and Education Publishing
dc.identifier.citationEscobedo-Moratilla, A. , Velarde-Salcedo, A. J. , Magaña-Hernández, C. V. , Barrera-Pacheco, A. , Espitia-Rangel, E. , Herrera-Estrella, A. , & Rosa, A. P. B. D. L. (2017). Amaranth Protein Improves Lipid Profile and Insulin Resistance in a Diet-induced Obese Mice Model. Journal of Food and Nutrition Research, 5(12), 914-924.
dc.description.abstract"Amaranth has been claimed as functional food, but its function on obesity-related disorder is not fully known. The aim of this study was to analyse the effect of amaranth protein intake on blood lipids profile and insulin resistance in diet-induced obese mice. The effect of soybean protein was also analysed for comparative purposes. C57BL-6 mice were fed for eight weeks with regular or high fat diet. Amaranth or soybean protein isolates (10 mg/kg) were supplied via oral administration. Changes in body weight, adipose tissue, total cholesterol, triglycerides, insulin, a glucose tolerance test, as well as the expression of lipid metabolism-related genes were measured. Our results have shown that amaranth protein induces a decrease in plasma insulin in mice fed with a regular diet, whereas a decrease in triglycerides was observed in mice fed with high fat diet. Furthermore, down-regulation of Tnf-? and Res, suggested the inhibition of inflammation state. The present study demonstrates that amaranth protein, but not soybean protein, improves the obese mice health, and the hormonal modulation (Lep, Fasn, Lpl) could lead to new mechanism of action by which amaranth consumption exerts its beneficial health effect."
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.subjectInsulin resistance
dc.subjectProtein isolate
dc.subject.classificationBIOLOGÍA MOLECULAR
dc.titleAmaranth protein improves lipid profile and insulin resistance in a diet-induced obese mice model
dc.rights.accessAcceso Abierto

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional