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Cytotoxicity induced by carbon nanotubes in experimental malignant glioma

dc.contributor.authorRomano Feinholz, Samuel
dc.contributor.authorSalazar Ramiro, Alelí
dc.contributor.authorMuñoz Sandoval, Emilio
dc.contributor.authorMagaña Maldonado, Roxana
dc.contributor.authorHernández Pedro, Norma
dc.contributor.authorRangel López, Edgar
dc.contributor.authorGonzález Aguilar, Alberto
dc.contributor.authorSánchez García, Aurora
dc.contributor.authorSotelo, Julio
dc.contributor.authorPérez de la Cruz, Verónica
dc.contributor.authorPineda, Benjamín
dc.identifier.citationRomano-Feinholz, S., Salazar-Ramiro, A., Muñoz-Sandoval, E., Magaña-Maldonado, R., Hernández Pedro, N., Rangel López, E., … Pineda, B. (2017). Cytotoxicity induced by carbon nanotubes in experimental malignant glioma. International Journal of Nanomedicine, 12, 6005–6026.
dc.description.abstract"Despite multiple advances in the diagnosis of brain tumors, there is no effective treatment for glioblastoma. Multiwalled carbon nanotubes (MWCNTs), which were previously used as a diagnostic and drug delivery tool, have now been explored as a possible therapy against neoplasms. However, although the toxicity profile of nanotubes is dependent on the physicochemical characteristics of specific particles, there are no studies exploring how the effectivity of the carbon nanotubes (CNTs) is affected by different methods of production. In this study, we characterize the structure and biocompatibility of four different types of MWCNTs in rat astrocytes and in RG2 glioma cells as well as the induction of cell lysis and possible additive effect of the combination of MWCNTs with temozolomide. We used undoped MWCNTs (labeled simply as MWCNTs) and nitrogen-doped MWCNTs (labeled as N-MWCNTs). The average diameter of both pristine MWCNTs and pristine N-MWCNTs was ~22 and ~35 nm, respectively. In vitro and in vivo results suggested that these CNTs can be used as adjuvant therapy along with the standard treatment to increase the survival of rats implanted with malignant glioma."es_MX
dc.publisherDove Press Ltdes_MX
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.subjectCarbon nanotubeses_MX
dc.subjectGlioblastoma therapyes_MX
dc.subjectMalignant gliomaes_MX
dc.titleCytotoxicity induced by carbon nanotubes in experimental malignant gliomaes_MX

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional