Show simple item record


Adhesins in Candida glabrata

dc.contributor.authorTimmermans, Bea
dc.contributor.authorDe Las Peñas Nava, Alejandro
dc.contributor.authorCastaño Navarro, Irene Beatriz
dc.contributor.authorVan Dijck, Patrick
dc.identifier.citationTimmermans, B.; De Las Peñas, A.; Castaño, I.; Van Dijck, P. Adhesins in Candida glabrata. J. Fungi 2018, 4, 60.
dc.description.abstract"The human fungal pathogen Candida glabrata is causing more and more problems in hospitals, as this species shows an intrinsic antifungal drug resistance or rapidly becomes resistant when challenged with antifungals. C. glabrata only grows in the yeast form, so it is lacking a yeast-to-hyphae switch, which is one of the main virulence factors of C. albicans. An important virulence factor of C. glabrata is its capacity to strongly adhere to many different substrates. To achieve this, C. glabrata expresses a large number of adhesin-encoding genes and genome comparisons with closely related species, including the non-pathogenic S. cerevisiae, which revealed a correlation between the number of adhesin-encoding genes and pathogenicity. The adhesins are involved in the first steps during an infection; they are the first point of contact with the host. For several of these adhesins, their importance in adherence to different substrates and subsequent biofilm formation was demonstrated in vitro or in vivo. In this review, we provide an overview of the role of C. glabrata adhesins during adhesion and biofilm formation both, under in vitro and in vivo conditions."
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.subjectCandida glabrata
dc.titleAdhesins in Candida glabrata
dc.rights.accessAcceso Abierto

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional