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Evolutionary Variation in MADS Box Dimerization Affects Floral Development and Protein Abundance in Maize

dc.contributor.authorAbraham Juárez, María Jazmín
dc.contributor.authorSchrager Lavelle, Amanda
dc.contributor.authorMan, Jarrett
dc.contributor.authorWhipple, Clinton
dc.contributor.authorHandakumbura, Pubudu
dc.contributor.authorBabbitt, Courtney
dc.contributor.authorBartlett, Madelaine
dc.identifier.citationMaría Jazmín Abraham-Juárez, Amanda Schrager-Lavelle, Jarrett Man, Clinton Whipple, Pubudu Handakumbura, Courtney Babbitt, Madelaine Bartlett, Evolutionary Variation in MADS Box Dimerization Affects Floral Development and Protein Abundance in Maize, The Plant Cell, Volume 32, Issue 11, November 2020, Pages 3408–3424,
dc.description.abstract"Interactions between MADS box transcription factors are critical in the regulation of floral development, and shifting MADS box protein-protein interactions are predicted to have influenced floral evolution. However, precisely how evolutionary variation in protein-protein interactions affects MADS box protein function remains unknown. To assess the impact of changing MADS box protein-protein interactions on transcription factor function, we turned to the grasses, where interactions between B-class MADS box proteins vary. We tested the functional consequences of this evolutionary variability using maize (Zea mays) as an experimental system. We found that differential B-class dimerization was associated with subtle, quantitative differences in stamen shape. In contrast, differential dimerization resulted in large-scale changes to downstream gene expression. Differential dimerization also affected B-class complex composition and abundance, independent of transcript levels. This indicates that differential B-class dimerization affects protein degradation, revealing an important consequence for evolutionary variability in MADS box interactions. Our results highlight complexity in the evolution of developmental gene networks: changing protein-protein interactions could affect not only the composition of transcription factor complexes but also their degradation and persistence in developing flowers. Our results also show how coding change in a pleiotropic master regulator could have small, quantitative effects on development."
dc.publisherOxford University Press
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.subjectDifferential expression analysis
dc.subjectE3 ubiquitin ligase
dc.subjectTranscription factors
dc.subjectOrgan identity
dc.subjectFemale gametogenesis
dc.subjectFlower developmet
dc.subject.classificationBIOLOGÍA MOLECULAR
dc.titleEvolutionary Variation in MADS Box Dimerization Affects Floral Development and Protein Abundance in Maize
dc.rights.accessAcceso Abierto

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