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Evolutionary variation in MADS-box dimerization affects floral development and protein stability

dc.contributor.authorAbraham Juárez, María Jazmín
dc.contributor.authorSchrager Lavelle, Amanda
dc.contributor.authorMan, Jarrett
dc.contributor.authorWhipple, Clinton
dc.contributor.authorHandakumbura, Pubudu
dc.contributor.authorBabbitt, Courtney
dc.contributor.authorBartlett, Madelaine
dc.date.accessioned2021-06-10T20:08:23Z
dc.date.available2021-06-10T20:08:23Z
dc.date.issued2020
dc.identifier.citationMaría Jazmín Abraham-Juárez, Amanda Schrager-Lavelle, Jarrett Man, Clinton Whipple, Pubudu Handakumbura, Courtney Babbitt, Madelaine Bartlett, Evolutionary variation in MADS-box dimerization affects floral development and protein stability, bioRxiv 2020.03.09.984260; doi: https://doi.org/10.1101/2020.03.09.984260
dc.identifier.urihttp://hdl.handle.net/11627/5640
dc.description.abstract"Shifting interactions between MADS-box transcription factors may have been critical in the emergence of the flower, and in floral diversification. However, how evolutionary variation in MADS-box interactions affects the development and evolution of floral form remains unknown. Interactions between B-class MADS-box proteins are variable across the grass family. Here, we test the functional consequences of this evolutionary variability using maize as an experimental system. We found that differential B-class dimerization was associated with subtle, quantitative differences in stamen shape. In contrast, differential dimerization resulted in large-scale changes to protein complex composition and downstream gene expression. Differential dimerization also affected B-class complex abundance, independent of RNA levels. Thus, differential dimerization may affect protein stability. This reveals an important consequence for evolutionary variability in MADS-box interactions, adding complexity to the evolution of developmental gene networks. Our results show that floral development is robust to molecular change, even coding change in a master regulator of development. This robustness may contribute to the evolvability of floral form."
dc.publisherCold Spring Harbor Laboratory
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.classificationBIOLOGÍA MOLECULAR
dc.titleEvolutionary variation in MADS-box dimerization affects floral development and protein stability
dc.typearticle
dc.identifier.doihttps://doi.org/10.1101/2020.03.09.984260
dc.rights.accessAcceso Abierto


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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