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Antilymphoma Effect of Incomptine A: In Vivo, In Silico, and Toxicological Studies

dc.contributor.authorCalzada, Fernando
dc.contributor.authorBautista Redonda, Francisco Elihú
dc.contributor.authorHidalgo Figueroa, Sergio Nemorio
dc.contributor.authorGarcía Hernández, Normand
dc.contributor.authorBarbosa Cabrera, Reyna Elizabeth
dc.contributor.authorVelázquez, Claudia
dc.contributor.authorOrdoñez Razo, Rosa María
dc.contributor.authorArietta García, Angel Giovanni
dc.identifier.citationCalzada, F.; Bautista, E.; Hidalgo-Figueroa, S.; García-Hernández, N.; Barbosa, E.; Velázquez, C.; Ordoñez-Razo, R.M.; Arietta-García, A.G. Antilymphoma Effect of Incomptine A: In Vivo, In Silico, and Toxicological Studies. Molecules 2021, 26, 6646.
dc.description.abstract"Incomptine A (IA) is a sesquiterpene lactone isolated from Decachaeta incompta that induces apoptosis, reactive oxygen species production, and a differential protein expression on the U-937 (diffuse histiocytic lymphoma) cell line. In this work, the antitumor potential of IA was investigated on Balb/c mice inoculated with U-937 cells and through the brine shrimp lethality (BSL) test. Furthermore, IA was subjected to molecular docking study using as targets proteins associated with processes of cancer as apoptosis, oxidative stress, and glycolytic metabolism. In addition to determining the potential toxicity of IA in human, its acute toxicity was performed in mice. Results reveals that IA showed high antilymphoma activity and BSL with an EC50 of 2.4 mg/kg and LC50 16.7 µg/mL, respectively. The molecular docking study revealed that IA has strong interaction on all targets used. In the acute oral toxicity, IA had a LD50 of 149 mg/kg. The results showed that the activities of IA including antilymphoma activity, BSL, acute toxicity, and in silico interactions were close to the methotrexate, an anticancer drug used as positive control. These findings suggest that IA may serve as a candidate for the development of a new drug to combat lymphoma.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.subjectIncomptine A
dc.subjectAntilymphoma activity
dc.subjectMolecular docking
dc.subjectAcute toxicity
dc.subjectBrine shrimp lethality
dc.subjectNon-Hodgkin lymphoma
dc.subject.classificationBIOLOGÍA MOLECULAR
dc.titleAntilymphoma Effect of Incomptine A: In Vivo, In Silico, and Toxicological Studies
dc.rights.accessAcceso Abierto

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional