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Environmental Nanoparticles Reach Human Fetal Brains

dc.contributor.authorCalderón Garcidueñas, Lilian
dc.contributor.authorPérez Calatayud, Ángel Augusto
dc.contributor.authorGonzález Maciel, Angélica
dc.contributor.authorReynoso Robles, Rafael
dc.contributor.authorSilva Pereyra, Héctor Gabriel
dc.contributor.authorRamos Morales, Andrea
dc.contributor.authorTorres Jardón, Ricardo
dc.contributor.authorSoberanes Cerino, Candelario de Jesús
dc.contributor.authorCarrillo Esper, Raúl
dc.contributor.authorBriones-Garduno, Jesús Carlos
dc.contributor.authorConde Gutiérrez, Yazmin del Socorro
dc.date.accessioned2023-06-14T16:12:18Z
dc.date.available2023-06-14T16:12:18Z
dc.date.issued2022
dc.identifier.citationCalderón-Garcidueñas, L.; Pérez-Calatayud, Á.A.; González-Maciel, A.; Reynoso-Robles, R.; Silva-Pereyra, H.G.; Ramos-Morales, A.; Torres-Jardón, R.; Soberanes-Cerino, C.d.J.; Carrillo-Esper, R.; Briones-Garduño, J.C.; Conde-Gutiérrez, Y.d.S. Environmental Nanoparticles Reach Human Fetal Brains. Biomedicines 2022, 10, 410. https://doi.org/10.3390/biomedicines10020410
dc.identifier.urihttp://hdl.handle.net/11627/6317
dc.description.abstract"Anthropogenic ultrafine particulate matter (UFPM) and industrial and natural nanoparticles (NPs) are ubiquitous. Normal term, preeclamptic, and postconceptional weeks(PCW) 8–15 human placentas and brains from polluted Mexican cities were analyzed by TEM and energy-dispersive X-ray spectroscopy. We documented NPs in maternal erythrocytes, early syncytiotrophoblast, Hofbauer cells, and fetal endothelium (ECs). Fetal ECs exhibited caveolar NP activity and widespread erythroblast contact. Brain ECs displayed micropodial extensions reaching luminal NP-loaded erythroblasts. Neurons and primitive glia displayed nuclear, organelle, and cytoplasmic NPs in both singles and conglomerates. Nanoscale Fe, Ti, and Al alloys, Hg, Cu, Ca, Sn, and Si were detected in placentas and fetal brains. Preeclamptic fetal blood NP vesicles are prospective neonate UFPM exposure biomarkers. NPs are reaching brain tissues at the early developmental PCW 8–15 stage, and NPs in maternal and fetal placental tissue compartments strongly suggests the placental barrier is not limiting the access of environmental NPs. Erythroblasts are the main early NP carriers to fetal tissues. The passage of UFPM/NPs from mothers to fetuses is documented and fingerprinting placental single particle composition could be useful for postnatal risk assessments. Fetal brain combustion and industrial NPs raise medical concerns about prenatal and postnatal health, including neurological and neurodegenerative lifelong consequences."
dc.publisherMDPI
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectEnvironmental medicine
dc.subjectPlacental impairment
dc.subjectNeurodevelopmental disorders
dc.subjectFetal brains
dc.subjectErythroblasts
dc.subjectPreeclampsia
dc.subjectNanoparticles
dc.subjectNPs extracellular vesicles
dc.subjectPetrochemical pollution
dc.subjectVillahermosa
dc.subjectTabasco
dc.subject.classificationBIOQUÍMICA
dc.titleEnvironmental Nanoparticles Reach Human Fetal Brains
dc.typearticle
dc.identifier.doihttps://doi.org/10.3390/biomedicines10020410
dc.rights.accessAcceso Abierto


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional