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Neuropharmacological Activities of Ceiba aesculifolia (Kunth) Britten & Baker f (Malvaceae)

dc.contributor.authorBustos Gómez, Chrystyan Iván
dc.contributor.authorGasca Martínez, Deisy
dc.contributor.authorYáñez Barrientos. Eunice
dc.contributor.authorHidalgo Figueroa, Sergio Nemorio
dc.contributor.authorGonzález Rivera, María Leonor
dc.contributor.authorBarragan Galvez, Juan Carlos
dc.contributor.authorZapata Morales, Juan Ramón
dc.contributor.authorIsiordia Espinoza, Mario Alberto
dc.contributor.authorCorrales Escobosa, Alma Rosa
dc.contributor.authorAlonso Castro, Angel Josabab
dc.identifier.citationBustos-Gómez, C.I.; Gasca-Martínez, D.; Yáñez-Barrientos, E.; Hidalgo-Figueroa, S.; Gonzalez-Rivera, M.L.; Barragan-Galvez, J.C.; Zapata-Morales, J.R.; Isiordia-Espinoza, M.; Corrales-Escobosa, A.R.; Alonso-Castro, A.J. Neuropharmacological Activities of Ceiba aesculifolia (Kunth) Britten & Baker f (Malvaceae). Pharmaceuticals 2022, 15, 1580.
dc.description.abstract"Ceiba aesculifolia (Kunth) Britten & Baker f (Malvaceae) is used for the folk treatment of mood disorders. C. aesculifolia bark was extracted in ethanol, and the extract (CAE) was chemically standardized using gas chromatography–mass spectrometry (GC-MS). This study evaluated the effects of CAE (10–100 mg/kg p.o.) on anxiolytic-like activity, sedation, locomotor activity, depression-like activity, and spatial working memory using in vivo rodent models. A possible mechanism for the anxiolytic-like and antidepressant-like actions induced by CAE was assessed using neurotransmission pathway inhibitors. Myristic acid was one of the compounds found in CAE using GC-MS. This study also evaluated the anxiolytic-like activity and the sedative actions of myristic acid and assessed a possible mechanism of action using neurotransmission pathway inhibitors and an in silico analysis. CAE elicited anxiolytic-like activity and antidepressant-like effects (ED50 = 57 mg/kg). CAE (10–100 mg/kg) did not affect locomotor coordination or induce sedation. The anxiolytic-like and antidepressant-like actions of CAE were reverted by prazosin, suggesting a possible participation of the noradrenergic system. The anxiolytic-like activity of myristic acid was reverted by the co-administration of prazosin and partially reverted by ketanserin. The docking study revealed that myristic acid can form favorable interactions within 5-HT2A and ?1A-adrenoreceptor binding pockets."
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.subjectAnxiolytic-like activity
dc.subjectAntidepressant-like activity
dc.subjectTraditional medicine
dc.subjectAdrenergic system
dc.subjectMyristic acid
dc.titleNeuropharmacological Activities of Ceiba aesculifolia (Kunth) Britten & Baker f (Malvaceae)
dc.rights.accessAcceso Abierto

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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