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Revealing the contribution of astrocytes to glutamatergic neuronal transmission

dc.contributor.authorCuellar Santoyo, Ares Orlando
dc.contributor.authorRuiz Rodríguez, Víctor Manuel
dc.contributor.authorMares Barbosa, Teresa Belem
dc.contributor.authorPatrón Soberano, Olga Araceli
dc.contributor.authorHowe, Andrew G.
dc.contributor.authorPortales Pérez, Diana Patricia
dc.contributor.authorMiquelajáuregui Graf, Amaya
dc.contributor.authorEstrada Sánchez, Ana María
dc.date.accessioned2024-05-30T21:28:23Z
dc.date.available2024-05-30T21:28:23Z
dc.date.issued2023
dc.identifier.citationCuellar-Santoyo AO, Ruiz-Rodríguez VM, Mares-Barbosa TB, Patrón-Soberano A, Howe AG, Portales-Pérez DP, Miquelajáuregui Graf A and Estrada-Sánchez AM (2023) Revealing the contribution of astrocytes to glutamatergic neuronal transmission. Front. Cell. Neurosci. 16:1037641. doi: 10.3389/fncel.2022.1037641
dc.identifier.urihttp://hdl.handle.net/11627/6548
dc.description.abstractResearch on glutamatergic neurotransmission has focused mainly on the function of presynaptic and postsynaptic neurons, leaving astrocytes with a secondary role only to ensure successful neurotransmission. However, recent evidence indicates that astrocytes contribute actively and even regulate neuronal transmission at different levels. This review establishes a framework by comparing glutamatergic components between neurons and astrocytes to examine how astrocytes modulate or otherwise influence neuronal transmission. We have included the most recent findings about the role of astrocytes in neurotransmission, allowing us to understand the complex network of neuron-astrocyte interactions. However, despite the knowledge of synaptic modulation by astrocytes, their contribution to specific physiological and pathological conditions remains to be elucidated. A full understanding of the astrocyte’s role in neuronal processing could open fruitful new frontiers in the development of therapeutic applications.
dc.publisherFrontiers Media S.A.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCalcium
dc.subjectGliotransmission
dc.subjectNMDA receptors
dc.subjectGLT-1
dc.subjectGLAST
dc.subjectVGLUT1
dc.subjectxCT
dc.subject.classificationNEUROCIENCIAS
dc.titleRevealing the contribution of astrocytes to glutamatergic neuronal transmission
dc.typearticle
dc.identifier.doihttps://doi.org/10.3389/fncel.2022.1037641
dc.rights.accessAcceso Abierto


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional