Show simple item record

Title

Editorial: New insight into Huntington's disease: From neuropathology to possible therapeutic targets

dc.contributor.authorEstrada Sánchez, Ana María
dc.contributor.authorRebec, George V.
dc.contributor.authorGalvan, Laurie
dc.date.accessioned2024-05-30T21:28:25Z
dc.date.available2024-05-30T21:28:25Z
dc.date.issued2023
dc.identifier.citationEstrada-Sánchez AM, Rebec GV and Galvan L (2023) Editorial: New insight into Huntington’s disease: From neuropathology to possible therapeutic targets. Front. Neurosci. 17:1138712. doi: 10.3389/fnins.2023.1138712
dc.identifier.urihttp://hdl.handle.net/11627/6553
dc.description.abstractIn 1872, George Huntington described an illness that is “confined to certain families… in whose veins the seeds of the disease are known to exist.” That seed was later identified as the expansion of the cytosine-adenine-guanine (CAG) repeats within the huntingtin gene that leads to an expanded glutamine repeat tract in the N-terminal end of the huntingtin protein (Gusella et al., 1983; MacDonald et al., 1993; Huntington, 2003). This illness is known as Huntington's disease and depending on the length of the expanded glutamine tract, it can manifest during childhood or adulthood. In the former, the main phenotypical alterations are body rigidity and epileptic seizures. The presence of psychiatric disturbances, the progressive development of generalized involuntary movements, and dementia characterize the onset of Huntington's disease during adulthood.
dc.publisherFrontiers Media S.A.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMutant huntingtin
dc.subjectAcanthocytes
dc.subjectIrritable behavior
dc.subjectInterneurons
dc.subjectCortex
dc.subjectHypothalamus
dc.subjectCalcium imaging
dc.subject.classificationNEUROCIENCIAS
dc.titleEditorial: New insight into Huntington's disease: From neuropathology to possible therapeutic targets
dc.typearticle
dc.identifier.doihttps://doi.org/10.3389/fnins.2023.1138712
dc.rights.accessAcceso Abierto


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional