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In Vivo Neuropharmacological Effects of Neophytadiene

dc.contributor.authorGonzález Rivera, María Leonor
dc.contributor.authorBarragan Galvez, Juan Carlos
dc.contributor.authorGasca Martínez, Deisy
dc.contributor.authorHidalgo Figueroa, Sergio Nemorio
dc.contributor.authorIsiordia Espinoza, Mario Alberto
dc.contributor.authorAlonso Castro, Angel Josabab
dc.date.accessioned2024-05-30T21:28:35Z
dc.date.available2024-05-30T21:28:35Z
dc.date.issued2023
dc.identifier.citationGonzalez-Rivera, M.L.; Barragan-Galvez, J.C.; Gasca-Martínez, D.; Hidalgo-Figueroa, S.; Isiordia-Espinoza, M.; Alonso-Castro, A.J. In Vivo Neuropharmacological Effects of Neophytadiene. Molecules 2023, 28, 3457. https://doi.org/10.3390/molecules28083457
dc.identifier.urihttp://hdl.handle.net/11627/6570
dc.description.abstractNeophytadiene (NPT) is a diterpene found in the methanolic extracts of Crataeva nurvala and Blumea lacera, plants reported with anxiolytic-like activity, sedative properties, and antidepressant-like actions; however, the contribution of neophytadiene to these effects is unknown. This study determined the neuropharmacological (anxiolytic-like, antidepressant-like, anticonvulsant, and sedative) effects of neophytadiene (0.1–10 mg/kg p.o.) and determined the mechanisms of action involved in the neuropharmacological actions using inhibitors such as flumazenil and analyzing the possible interaction of neophytadiene with GABA receptors using a molecular docking study. The behavioral tests were evaluated using the light–dark box, elevated plus-maze, open field, hole-board, convulsion, tail suspension, pentobarbital-induced sleeping, and rotarod. The results showed that neophytadiene exhibited anxiolytic-like activity only to the high dose (10 mg/kg) in the elevated plus-maze and hole-board tests, and anticonvulsant actions in the 4-aminopyridine and pentylenetetrazole-induced seizures test. The anxiolytic-like and anticonvulsant effects of neophytadiene were abolished with the pre-treatment with 2 mg/kg flumazenil. In addition, neophytadiene showed low antidepressant effects (about 3-fold lower) compared to fluoxetine. On other hand, neophytadiene had no sedative or locomotor effects. In conclusion, neophytadiene exerts anxiolytic-like and anticonvulsant activities with the probable participation of the GABAergic system.
dc.publisherMDPI
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectNeophytadiene
dc.subjectAnxiety
dc.subjectConvulsion
dc.subjectDiterpene
dc.subject.classificationBIOQUÍMICA
dc.titleIn Vivo Neuropharmacological Effects of Neophytadiene
dc.typearticle
dc.identifier.doihttps://doi.org/10.3390/molecules28083457
dc.rights.accessAcceso Abierto


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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