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Neuropharmacological Effects of the Dichloromethane Extract from the Stems of Argemone ochroleuca Sweet (Papaveraceae) and Its Active Compound Dihydrosanguinarine

dc.contributor.authorYáñez Barrientos Eunice
dc.contributor.authorBarragan Galvez, Juan Carlos
dc.contributor.authorHidalgo Figueroa, Sergio Nemorio
dc.contributor.authorReyes Luna, Alfonso
dc.contributor.authorGonzález Rivera, María Leonor
dc.contributor.authorCruz Cruz, David
dc.contributor.authorIsiordia Espinoza, Mario Alberto
dc.contributor.authorDeveze Álvarez, Martha Alicia
dc.contributor.authorVillegas Gómez, Clarisa
dc.contributor.authorAlonso Castro, Angel Josabab
dc.date.accessioned2024-05-30T21:28:37Z
dc.date.available2024-05-30T21:28:37Z
dc.date.issued2023
dc.identifier.citationYáñez-Barrientos, E.; Barragan-Galvez, J.C.; Hidalgo-Figueroa, S.; Reyes-Luna, A.; Gonzalez-Rivera, M.L.; Cruz Cruz, D.; Isiordia-Espinoza, M.A.; Deveze-Álvarez, M.A.; Villegas Gómez, C.; Alonso-Castro, A.J. Neuropharmacological Effects of the Dichloromethane Extract from the Stems of Argemone ochroleuca Sweet (Papaveraceae) and Its Active Compound Dihydrosanguinarine. Pharmaceuticals 2023, 16, 1175. https://doi.org/10.3390/ph16081175
dc.identifier.urihttp://hdl.handle.net/11627/6574
dc.description.abstractArgemone ochroleuca Sweet (Papaveraceae) is used in folk medicine as a sedative and hypnotic agent. This study aimed to evaluate the anxiolytic-like, sedative, antidepressant-like, and anticonvulsant activities of a dichloromethane extract of A. ochroleuca stems (AOE), chemically standardized using gas chromatography–mass spectrometry (GC–MS), and its active compound dihydrosanguinarine (DHS). The anxiolytic-like, sedative, antidepressant-like, and anticonvulsant activities of the AOE (0.1–50 mg/kg p.o.) and DHS (0.1–10 mg/kg p.o.) were evaluated using murine models. A possible mechanism for the neurological actions induced by the AOE or DHS was assessed using inhibitors of neurotransmission pathways and molecular docking. Effective dose 50 (ED50) values were calculated by a linear regression analysis. The AOE showed anxiolytic-like activity in the cylinder exploratory test (ED50 = 33 mg/kg), and antidepressant-like effects in the forced swimming test (ED50 = 3 mg/kg) and the tail suspension test (ED50 = 23 mg/kg), whereas DHS showed anxiolytic-like activity (ED50 = 2 mg/kg) in the hole board test. The AOE (1–50 mg/kg) showed no locomotive affectations or sedation in mice. A docking study revealed the affinity of DHS for ?2-adrenoreceptors and GABAA receptors. The anxiolytic-like and anticonvulsant effects of the AOE are due to GABAergic participation, whereas the antidepressant-like effects of the AOE are due to the noradrenergic system. The noradrenergic and GABAergic systems are involved in the anxiolytic-like actions of DHS.
dc.publisherMDPI
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectArgemone ochroleuca Sweet
dc.subjectAnxiolytic
dc.subjectAntidepressant
dc.subjectAnticonvulsant
dc.subject.classificationFARMACOLOGÍA
dc.titleNeuropharmacological Effects of the Dichloromethane Extract from the Stems of Argemone ochroleuca Sweet (Papaveraceae) and Its Active Compound Dihydrosanguinarine
dc.typearticle
dc.identifier.doihttps://doi.org/10.3390/ph16081175
dc.rights.accessAcceso Abierto


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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