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Expansion of human hematopoietic stem cells for transplantation: trends and perspectives

dc.contributor.authorZaldivar Andrade, Hera
dc.contributor.authorSantos Martínez, Martha Leticia
dc.contributor.authorDe León Rodríguez, Antonio
dc.contributor.editorSpringer
dc.date.accessioned2018-06-07T20:16:41Z
dc.date.available2018-06-07T20:16:41Z
dc.date.issued2008-03
dc.identifier.citationAndrade-Zaldívar, H., Santos, L. & De León Rodríguez, A. Cytotechnology (2008) 56: 151. https://doi.org/10.1007/s10616-008-9144-1
dc.identifier.urihttp://hdl.handle.net/11627/3849
dc.description.abstract"Umbilical cord blood transplantation is clinically limited by its low progenitor cell content. Ex vivo expansion has become an alternative to increase the cell dose available for transplants. Expansion has been evaluated in several ways such as static cultures combining growth factors or mimicking the natural microenvironment using co-culture systems. However, static cultures have a small volume capacity and therefore large-scale expansion has been addressed using bioreactors. These and other biotechnological approaches for the expansion of hematopoietic progenitors and their utility to study several aspects of hematopoietic stem cell biology are discussed here."
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject2D-culture
dc.subject3D-culture
dc.subjectHuman cells
dc.subjectLeukemia
dc.subjectRotating wall vessel
dc.subjectStirred tank
dc.subjectTransplant
dc.subject.classificationCIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA
dc.titleExpansion of human hematopoietic stem cells for transplantation: trends and perspectives
dc.typearticle
dc.identifier.doihttps://doi.org/10.1007/s10616-008-9144-1
dc.rights.accessAcceso Abierto


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional