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Multistability in a prion replication interconnected cell reaction network

dc.contributor.authorMéndez González, José Martín
dc.contributor.authorOtero Muras, Irene
dc.date.accessioned2019-08-09T22:22:40Z
dc.date.available2019-08-09T22:22:40Z
dc.date.issued2018
dc.identifier.citationJ.M. Méndez-González, Irene Otero-Muras, Multistability in a prion replication interconnected cell reaction network??First author acknowledge the financial support from Red de Proteínas, Priones y Enfermedades Neurodegenerativas (PRyEND) http://www.pryend.org/ IOM Acknowledges funding from the Spanish MINECO (and the European Regional Development Fund) project SYNBIOFACTORY (grant number DPI2014-55276-C5-2-R)., IFAC-PapersOnLine, Volume 51, Issue 19, 2018, Pages 62-63.
dc.identifier.urihttp://hdl.handle.net/11627/5025
dc.description.abstract"Aggregation of misfolded proteins has been implicated in a number of neurodegenerative disorders including prion disease. In spite of intensive research, the detailed mechanisms of protein misfolding leading to protein aggregation remain unsolved. Here, we explore the capacity for bistability of several classes of mechanisms proposed in the literature and compatible with protein aggregation kinetic data sets (it has been shown that bistability explains thresholds phenomena observed in protein aggregation in vitro and in vivo). Using a novel method for bistability detection we find a plausible scenario for which the so called subsequent monomer addition model leads to bistability."
dc.publisherInternational Federation of Automatic Control
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBistability
dc.subjectPrion kinetics
dc.subjectInterconnected cells
dc.subjectBiochemical Reaction Network
dc.subject.classificationMATEMÁTICAS
dc.titleMultistability in a prion replication interconnected cell reaction network
dc.typearticle
dc.identifier.doihttps://doi.org/10.1016/j.ifacol.2018.09.043
dc.rights.accessAcceso Abierto


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional