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Genotyping of the MTL loci and susceptibility to two antifungal agents of Candida glabrata clinical isolates

dc.contributor.authorLevaniegos Sobrino, María Teresa de Fátima
dc.contributor.authorRamírez Zavaleta, Candy Yuriria
dc.contributor.authorSifuentes Osornio, José
dc.contributor.authorBobadilla del Valle, Judith Miriam
dc.contributor.authorDe Las Peñas Nava, Alejandro
dc.contributor.authorCastaño Navarro, Irene Beatriz
dc.contributor.editorInstituto Oswaldo Cruz
dc.date.accessioned2018-03-23T23:59:41Z
dc.date.available2018-03-23T23:59:41Z
dc.date.issued2009-08
dc.identifier.citationLavaniegos-Sobrino, María Teresa, Ramírez-Zavaleta, Candy Y, Ponce de León, Alfredo, Sifuentes-Osornio, José, Bobadilla-Del Valle, Miriam, Rangel-Cordero, Andrea, De Las Peñas, Alejandro, & Castaño, Irene. (2009). Genotyping of the MTL loci and susceptibility to two antifungal agents of Candida glabrata clinical isolates. Memórias do Instituto Oswaldo Cruz, 104(5), 775-782.
dc.identifier.urihttp://hdl.handle.net/11627/3709
dc.description.abstract"The opportunistic fungal pathogen Candida glabrata is the second most common isolate from bloodstream infections worldwide and is naturally less susceptible to the antifungal drug fluconazole than other Candida species. C. glabrata is a haploid yeast that contains three mating-type like loci (MTL), although no sexual cycle has been described. Strains containing both types of mating information at the MTL1 locus are found in clinical isolates, but it is thought that strains containing type a information are more common. Here we investigated if a particular combination of mating type information at each MTL locus is more prevalent in clinical isolates from hospitalized patients in Mexico and if there is a correlation between mating information and resistance to fluconazole and 5- fluorocytosine. We found that while both types of information at MTL1 are equally represented in a collection of 64 clinical isolates, the vast majority of isolates contain a-type information at MTL2 and a-type at MTL3. We also found no correlation of the particular combination of mating type information at the three MTL loci and resistance to fluconazole."
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.classificationBIOLOGÍA Y QUÍMICA
dc.titleGenotyping of the MTL loci and susceptibility to two antifungal agents of Candida glabrata clinical isolates
dc.typearticle
dc.identifier.doihttps://dx.doi.org/10.1590/S0074-02762009000500019
dc.rights.accessAcceso Abierto


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional