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Protection of silver nanoparticles using Eysenhardtia polystachya in peroxide-induced pancreatic beta-Cell damage and their antidiabetic properties in zebrafish

dc.contributor.authorGarcía Campoy, Abraham Heriberto
dc.contributor.authorPérez Gutiérrez, Rosa Martha
dc.contributor.authorManriquez Alvirde, Gabriela
dc.contributor.authorMuñiz Ramirez, Alethia
dc.contributor.editorDove Press Ltd
dc.date.accessioned2018-12-13T21:09:19Z
dc.date.available2018-12-13T21:09:19Z
dc.date.issued2018
dc.identifier.citationGarcia Campoy, A. H., Perez Gutierrez, R. M., Manriquez-Alvirde, G., & Muñiz Ramirez, A. (2018). Protection of silver nanoparticles using Eysenhardtia polystachya in peroxide-induced pancreatic β-Cell damage and their antidiabetic properties in zebrafish. International journal of nanomedicine, 13, 2601-2612. doi:10.2147/IJN.S163714
dc.identifier.urihttp://hdl.handle.net/11627/4812
dc.description.abstract"Background: The aim was to explore the efficacy of extract of Eysenhardtia polystachya-loaded silver nanoparticles (EP/AgNPs) on pancreatic β cells, INS-1 cells, and zebrafish as a valuable model for the study of diabetes mellitus. Materials and methods: EP/AgNPs were synthesized using methanol/water bark extract of E. polystachya and characterized using various physicochemical techniques. Results: Immersion of adult zebrafish in 111 mM glucose solution resulted in a sustained hyperglycemic, hyperlipidemic state, and serum insulin levels decreased. The synthesized EP/AgNPs showed an absorption peak at 413 nm on ultraviolet–visible spectroscopy, revealing the surface plasmon resonance of the nanoparticles. Transmission electron microscopy indicated that most of the particles were spherical, with a diameter of 10–12 nm, a polydispersity index of 0.197, and a zeta potential of -32.25 mV, suggesting high stability of the nanoparticles. EP/AgNPs promote pancreatic β-cell survival, insulin secretion, enhanced hyperglycemia, and hyperlipidemia in glucose-induced diabetic zebrafish. EP/AgNPs also showed protection of the pancreatic β-cell line INS-1 against hydrogen peroxide-induced oxidative injury. Conclusion: The results indicate that EP/AgNPs have good antidiabetic activity and therefore could be used to prevent the development of diabetes."
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectEysenhardtia polystachya
dc.subjectZebrafish
dc.subjectSilver nanoparticles
dc.subjectDiabetes
dc.subjectInsulin
dc.subjectHyperlipidemia
dc.subject.classificationCIENCIAS TECNOLÓGICAS
dc.titleProtection of silver nanoparticles using Eysenhardtia polystachya in peroxide-induced pancreatic beta-Cell damage and their antidiabetic properties in zebrafish
dc.typearticle
dc.identifier.doihttps://doi.org/10.2147/IJN.S163714
dc.rights.accessAcceso Abierto


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional