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Candida glabrata’s genome plasticity confers a unique pattern of expressed cell wall proteins

dc.contributor.authorLópez-Fuentes, Eunice
dc.contributor.authorGutiérrez Escobedo, Ma Guadalupe
dc.contributor.authorTimmermans, Bea
dc.contributor.authorVan Dijck, Patrick
dc.contributor.authorDe Las Peñas Nava, Alejandro
dc.contributor.authorCastaño Navarro, Irene Beatriz
dc.date.accessioned2019-08-09T22:22:46Z
dc.date.available2019-08-09T22:22:46Z
dc.date.issued2018
dc.identifier.citationLópez-Fuentes, E.; Gutiérrez-Escobedo, G.; Timmermans, B.; Van Dijck, P.; De Las Peñas, A.; Castaño, I. Candida glabrata’s Genome Plasticity Confers a Unique Pattern of Expressed Cell Wall Proteins. J. Fungi 2018, 4, 67.
dc.identifier.urihttp://hdl.handle.net/11627/5040
dc.description.abstract"Candida glabrata is the second most common cause of candidemia, and its ability to adhere to different host cell types, to microorganisms, and to medical devices are important virulence factors. Here, we consider three characteristics that confer extraordinary advantages to C. glabrata within the host. (1) C. glabrata has a large number of genes encoding for adhesins most of which are localized at subtelomeric regions. The number and sequence of these genes varies substantially depending on the strain, indicating that C. glabrata can tolerate high genomic plasticity; (2) The largest family of CWPs (cell wall proteins) is the EPA (epithelial adhesin) family of adhesins. Epa1 is the major adhesin and mediates adherence to epithelial, endothelial and immune cells. Several layers of regulation like subtelomeric silencing, cis-acting regulatory regions, activators, nutritional signaling, and stress conditions tightly regulate the expression of many adhesin-encoding genes in C. glabrata, while many others are not expressed. Importantly, there is a connection between acquired resistance to xenobiotics and increased adherence; (3) Other subfamilies of adhesins mediate adherence to Candida albicans, allowing C. glabrata to efficiently invade the oral epithelium and form robust biofilms. It is noteworthy that every C. glabrata strain analyzed presents a unique pattern of CWPs at the cell surface."
dc.publisherMDPI
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCandida glabrata
dc.subjectCell wall proteins
dc.subjectAdherence
dc.subjectVirulence
dc.subjectFluconazole resistance
dc.subjectGenome plasticity
dc.subjectSubtelomeric silencing
dc.subjectClinical isolates
dc.subject.classificationMICROBIOLOGÍA
dc.titleCandida glabrata’s genome plasticity confers a unique pattern of expressed cell wall proteins
dc.typearticle
dc.identifier.doihttps://doi.org/10.3390/jof4020067
dc.rights.accessAcceso Abierto


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional