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Timbe (Acaciella angustissima) pods extracts reduce the levels of glucose, insulin and improved physiological parameters, hypolipidemic effect, oxidative stress and renal damage in streptozotocin-induced diabetic rats

dc.contributor.authorRodríguez Méndez, Adriana Jheny
dc.contributor.authorCarmen Sandoval, Wendy Monserrat
dc.contributor.authorLomas Soria, María Consuelo
dc.contributor.authorGuevara González, Ramón Gerardo
dc.contributor.authorReynoso Camacho, Rosalía
dc.contributor.authorVillagran Herrera, Ma. Elena
dc.contributor.authorSalazar Olivo, Luis Antonio
dc.contributor.authorTorres Pacheco, Irineo
dc.contributor.authorFeregrino Pérez, Ana Angelica
dc.date.accessioned2019-08-09T22:22:50Z
dc.date.available2019-08-09T22:22:50Z
dc.date.issued2018
dc.identifier.citationRodríguez-Méndez, A.J.; Carmen-Sandoval, W.; Lomas-Soria, C.; Guevara-González, R.G.; Reynoso-Camacho, R.; Villagran-Herrera, M.E.; Salazar-Olivo, L.; Torres-Pacheco, I.; Feregrino-Pérez, A.A. Timbe (Acaciella angustissima) Pods Extracts Reduce the Levels of Glucose, Insulin and Improved Physiological Parameters, Hypolipidemic Effect, Oxidative Stress and Renal Damage in Streptozotocin-Induced Diabetic Rats. Molecules 2018, 23, 2812.
dc.identifier.urihttp://hdl.handle.net/11627/5049
dc.description.abstract"In Mexico one in 14 deaths are caused by diabetes mellitus (DM) or by the macro and microvascular disorders derived from it. A continuous hyperglycemic state is characteristic of DM, resulting from a sustained state of insulin resistance and/or a dysfunction of ?-pancreatic cells. Acaciella angustissima is a little studied species showing a significant antioxidant activity that can be used as treatment of this disease or preventive against the complications. The objective of this study was to explore the effect of oral administration of A. angustissima methanol extract on physiological parameters of streptozotocin-induced diabetic rats. The results indicated a significant reduction in blood glucose levels, an increase in serum insulin concentration, a decrease in lipid levels and an improvement in the parameters of kidney damage by applying a concentration of 100 mg/Kg B.W. However, glucose uptake activity was not observed in the adipocyte assay. Moreover, the extract of A. angustissima displayed potential for the complementary treatment of diabetes and its complications likely due to the presence of bioactive compounds such as protocatechuic acid. This study demonstrated that methanol extract of Acacciella angustissima has an antidiabetic effect by reducing the levels of glucose, insulin and improved physiological parameters, hypolipidemic effect, oxidative stress and renal damage in diabetic rats."
dc.publisherMDPI
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAcacciella angustissima
dc.subjectStreptozotocin-diabetic rats
dc.subjectAntidiabetic effect
dc.subjectPolyphenolic
dc.subjectProtocatechuic acid
dc.subject.classificationBIOLOGÍA MOLECULAR
dc.titleTimbe (Acaciella angustissima) pods extracts reduce the levels of glucose, insulin and improved physiological parameters, hypolipidemic effect, oxidative stress and renal damage in streptozotocin-induced diabetic rats
dc.typearticle
dc.identifier.doihttps://doi.org/10.3390/molecules23112812
dc.rights.accessAcceso Abierto


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional