Show simple item record

Title

Evaluation of vascular tone and cardiac contractility in response to silver nanoparticles, using Langendorff rat heart preparation

dc.contributor.authorRamírez Lee, Manuel Alejandro
dc.contributor.authorMartínez Cuevas, Pedro Pablo
dc.contributor.authorRosas Hernández, Héctor
dc.contributor.authorOros Ovalle, Cuauhtémoc
dc.contributor.authorBravo Sánchez, Mariela
dc.contributor.authorMartínez Castañon, Gabriel Alejandro
dc.contributor.authorGonzález Castillo, María del Carmen
dc.date.accessioned2019-08-09T22:22:51Z
dc.date.available2019-08-09T22:22:51Z
dc.date.issued2017
dc.identifier.citationAlejandro Ramirez-Lee Manuel, Pedro Pablo Martinez-Cuevas, Hector Rosas-Hernandez, Cuauhtémoc Oros-Ovalle, Mariela Bravo-Sanchez, Gabriel Alejandro Martinez-Castañon, Carmen Gonzalez, Evaluation of vascular tone and cardiac contractility in response to silver nanoparticles, using Langendorff rat heart preparation, Nanomedicine: Nanotechnology, Biology and Medicine, Volume 13, Issue 4, 2017, Pages 1507-1518.
dc.identifier.urihttp://hdl.handle.net/11627/5051
dc.description.abstract"Silver nanoparticles (AgNPs) have been widely used because of their antimicrobial properties. However, several reports suggest that AgNPs exposure promote cardiac effects that involve nitric oxide (NO) and oxidative stress (OS). Nevertheless, there are no studies related to AgNPs-induced effects in cardiac physiology. The aim of this study was to evaluate the AgNPs direct actions on coronary vascular tone and cardiac contractility using Langendorff rat heart preparation. Low concentrations of AgNPs (0.1 and 1 ?g/mL) increased NO derived from inducible NO-synthase (iNOS), without modifying cardiac parameters. Meanwhile, high concentrations (10 and 100 ?g/mL) promoted a sustained vasoconstriction and increased cardiac contractility related to OS, leading to rhabdomyolysis. Furthermore, AgNPs were internalized in the cardiac muscle, hindering classic actions induced by phenylephrine (Phe) and acetylcholine (ACh). These data suggest that AgNPs affect cardiac physiology in function of the concentration and in part of the NO generation, NOS expression and OS."
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectSilver nanoparticles
dc.subjectCoronary vascular tone
dc.subjectMyocardial contractility
dc.subjectNitric oxide
dc.subjectOxidative stress
dc.subject.classificationCIENCIAS TECNOLÓGICAS
dc.titleEvaluation of vascular tone and cardiac contractility in response to silver nanoparticles, using Langendorff rat heart preparation
dc.typearticle
dc.identifier.doihttps://doi.org/10.1016/j.nano.2017.01.017
dc.rights.accessAcceso Abierto


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional