Robust H∞ control of glycemia in Type 2 Diabetes Mellitus via continous insulin plus Metformin

Abstract

"Several studies have shown that an adequate therapy for glycemic control in patients with type 2 diabetes mellitus (T2DM) can delay or prevent complications derived from this condition. To achieve the control objectives an adequate therapy should be performed by using insulin alone or in combination with an oral hypoglycemic agent. However, the key point of glycemic control is to determine the amount of insulin to be delivered. In order to achieve the above different strategies have been proposed, one of them is the design of feedback control algorithms. In this article a robust feedback control algorithm of glycemia in T2DM was designed. The algorithm determines the continuous insulin infusion to be delivered to maintain normoglycemia considering a combined therapy with a dose of metformin. The problem approach was to find a controller that minimized in the sense of the H? norm: i) the difference between the glycemia of a T2DM patient and a healthy subject (tracking problem) and ii) the effect of disturbances due to glucose intake and noise from a glucose sensor."