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Neuroprotective effects of ganoderma curtisii polysaccharides after kainic acid-seizure induced

dc.contributor.authorLeón Rivera, Ismael
dc.contributor.authorVilleda Hernández, Juana
dc.contributor.authorMontiel Arcos, Elizur
dc.contributor.authorTello, Isaac
dc.contributor.authorRios, María Yolanda
dc.contributor.authorEstrada Soto, Samuel
dc.contributor.authorAguilar Guadarrama, Angélica Berenice
dc.contributor.authorNúñez Urquiza, Verónica
dc.contributor.authorMéndez Mirón, Jazmín
dc.contributor.authorCampos Peña, Victoria
dc.contributor.authorHidalgo Figueroa, Sergio Nemorio
dc.contributor.authorHernández, Eva
dc.contributor.authorHurtado, Gerardo
dc.date.accessioned2020-03-12T23:37:05Z
dc.date.available2020-03-12T23:37:05Z
dc.date.issued2019
dc.identifier.citationLeon-Rivera I, Villeda-Hernandez J, Montiel-Arcos E, Tello I, Rios MY, Estrada-Soto S, et al. Neuroprotective Effects of Ganoderma curtisii Polysaccharides After Kainic Acid-Seizure Induced. Pharmacognosy Journal. 2019;11(5):1046-1054.
dc.identifier.urihttp://hdl.handle.net/11627/5311
dc.description.abstract"Background: Epilepsy is one of the major neurological disorders affecting world population. Although, some Ganoderma species have shown neuroprotective activities, the effects of polysaccharides isolated from Ganoderma curtisii on epileptic seizures have not been reported. Objective: The aims of the present study were to determine whether treatment with a polysaccharide fraction (GCPS-2) from a Mexican Ganoderma curtisii strain can reduce seizures, and the increases in the levels of apoptotic molecules and inflammatory cytokines in kainic acid-induced seizure mouse model. Materials and Methods: Rats were separated in groups: Control group received 2.5% Tween 20 solution; GCPS-2 groups were administered GCPS-2 (10, 40, or 80 mg/kg); KA group received KA 10 mg/kg; GCPS-2+KA received GCPS- 2 and 30 min later KA. Pathological changes in neuronal morphology, expression of B-cell lymphoma-2, and pro-inflammatory cytokines (interleukin1-? and tumor necrosis factor-?) in the rat hippocampus and cortex were determined by immunohistochemistry. Results: Ganoderma curtisii soluble polysaccharides (GCPS-2) inhibited convulsions in rats. Moreover, treatment with GCPS-2 reduced the increased levels of apoptotic signaling molecules (Bcl-2) and proinflammatory mediators (in the kainic acid-treated hippocampus and cortex). Conclusion: Ganoderma curtisii soluble polysaccharides have a neuroprotective potential against epilepsy, partially through its ability to inhibit neurotoxic events in the in vivo hippocampus and cortex."
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAnti-inflammatory
dc.subjectAnticonvulsant
dc.subjectGanoderma curtisii
dc.subjectNeuroprotective
dc.subjectβ-glucan
dc.subject.classificationFARMACOGNOSIA
dc.titleNeuroprotective effects of ganoderma curtisii polysaccharides after kainic acid-seizure induced
dc.typearticle
dc.identifier.doihttp://dx.doi.org/10.5530/pj.2019.11.164
dc.rights.accessAcceso Abierto


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional