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Mechanisms of fasting-mediated protection against renal injury and fibrosis development after ischemic acute kidney injury

dc.contributor.authorRojas Morales, Pedro
dc.contributor.authorTapia Rodríguez, Edilia
dc.contributor.authorLeón Contreras, Juan Carlos
dc.contributor.authorGonzález Reyes, Susana
dc.contributor.authorJiménez Osorio, Angélica Saraí
dc.contributor.authorTrujillo Silva, Daniela Joyce
dc.contributor.authorPavón Martínez, Natalia Ismene
dc.contributor.authorGranados Pineda, Jessica
dc.contributor.authorHernández Pando, Rogelio Enrique
dc.contributor.authorSánchez Lozada, Laura Gabriela
dc.contributor.authorOsorio Alonso, Horacio
dc.contributor.authorPedraza Chaverri, José
dc.date.accessioned2020-03-12T23:37:07Z
dc.date.available2020-03-12T23:37:07Z
dc.date.issued2019
dc.identifier.citationRojas-Morales, P.; Tapia, E.; León-Contreras, J.C.; González-Reyes, S.; Jiménez-Osorio, A.S.; Trujillo, J.; Pavón, N.; Granados-Pineda, J.; Hernández-Pando, R.; Sánchez-Lozada, L.G.; Osorio-Alonso, H.; Pedraza-Chaverri, J. Mechanisms of Fasting-Mediated Protection against Renal Injury and Fibrosis Development after Ischemic Acute Kidney Injury. Biomolecules 2019, 9, 404.
dc.identifier.urihttp://hdl.handle.net/11627/5315
dc.description.abstract"Ischemia-reperfusion injury of the kidney may lead to renal fibrosis through a combination of several mechanisms. We recently demonstrated that fasting protects the rat kidney against oxidative stress and mitochondrial dysfunction in early acute kidney injury, and also against fibrosis development. Here we show that preoperative fasting preserves redox status and mitochondrial homeostasis at the chronic phase of damage after severe ischemia. Also, the protective effect of fasting coincides with the suppression of inflammation and endoplasmic reticulum stress, as well as the down-regulation of the mechanistic target of rapamycin (mTOR) and extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathways in the fibrotic kidney. Our results demonstrate that fasting targets multiple pathophysiological mechanisms to prevent renal fibrosis and damage that results after renal ischemia-reperfusion injury."
dc.publisherMDPI
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectFasting
dc.subjectFibrosis
dc.subjectMitochondrial dysfunction
dc.subjectOxidative stress
dc.subjectInflammation
dc.subjectER stress
dc.subjectIschemia-reperfusion injury
dc.subject.classificationBIOLOGÍA VEGETAL (BOTÁNICA)
dc.titleMechanisms of fasting-mediated protection against renal injury and fibrosis development after ischemic acute kidney injury
dc.typearticle
dc.identifier.doihttps://doi.org/10.3390/biom9090404
dc.rights.accessAcceso Abierto


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional