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The Small GTPases in Fungal Signaling Conservation and Function

dc.contributor.authorDautt Castro, Mitzuko
dc.contributor.authorRosendo Vargas, Maria Montserrat
dc.contributor.authorCasas Flores, J. Sergio
dc.date.accessioned2022-03-10T19:33:25Z
dc.date.available2022-03-10T19:33:25Z
dc.date.issued2021
dc.identifier.citationDautt-Castro, M.; Rosendo-Vargas, M.; Casas-Flores, S. The Small GTPases in Fungal Signaling Conservation and Function. Cells 2021, 10, 1039. https://doi.org/10.3390/cells10051039
dc.identifier.urihttp://hdl.handle.net/11627/5745
dc.description.abstract"Monomeric GTPases, which belong to the Ras superfamily, are small proteins involved in many biological processes. They are fine-tuned regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Several families have been identified in organisms from different kingdoms. Overall, the most studied families are Ras, Rho, Rab, Ran, Arf, and Miro. Recently, a new family named Big Ras GTPases was reported. As a general rule, the proteins of all families have five characteristic motifs (G1–G5), and some specific features for each family have been described. Here, we present an exhaustive analysis of these small GTPase families in fungi, using 56 different genomes belonging to different phyla. For this purpose, we used distinct approaches such as phylogenetics and sequences analysis. The main functions described for monomeric GTPases in fungi include morphogenesis, secondary metabolism, vesicle trafficking, and virulence, which are discussed here. Their participation during fungus–plant interactions is reviewed as well."
dc.publisherMDPI
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectSmall GTPases
dc.subjectRas
dc.subjectRho
dc.subjectRab
dc.subjectRan
dc.subjectArf
dc.subjectMiro
dc.subjectBRG
dc.subjectFungi
dc.subject.classificationBIOLOGÍA CELULAR
dc.titleThe Small GTPases in Fungal Signaling Conservation and Function
dc.typearticle
dc.identifier.doihttps://doi.org/10.3390/cells10051039
dc.rights.accessAcceso Abierto


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional